Retrospective analysis of cases with Endometrial Cancer

Authors

  • Bulat Aytek Şık Istanbul Aydin University
  • Filiz Yarşılıkal Istanbul Kanuni Sultan Süleyman Education and Research Hospital
  • Serkan Kumbasar Sakarya University
  • Baki Erdem Istanbul Kanuni Sultan Süleyman Education and Research Hospital
  • Hanife Çopur Taksim Education and Research Hospital
  • Yılda Arzu Aba Bandırma Onyedi Eylül University

Keywords:

Endometrial cancer, Retrospective analysis, Prognosis

Abstract

We planned this study with the aim of determining histological types, clinical, surgical stage and grade of endometrial cancer cases which were followed-up and operated on in our clinic and giving an opinion on epidemiological features. Our study was a retrospective study consisted of 298 patients who had medical operations with the diagnosis of endometrial cancer. Endometrial cancer was diagnosed via dilatation and curettage. Routine preoperative examinations were wanted from the cases. Clinical stage was determined. After the diagnosis, total abdominal hysterectomy and bilateral salpingo-ooforectomy (TAH+BSO) were applied; while only pelvic lymph node dissection was applied on the patients who had good prognostic data, total pelvic and paraaortic lymph node dissection were applied to the group with bad prognostic data. All materials were examined in the pathology laboratory of our hospital. In endometrial cancer staging, FIGO surgical staging system -2009 was used. FIGO was used in grade classification and World Health Organization Classification of Tumors system was used for the histological classification. Our study was composed of 298 patients who had endometrial cancer. Of the patients who were included in the study, average age was 56.54±9.69, BMI average was 31.47±6.20, gravida average was 4.16±2.59, and parity average was 3.41±2.15. Distributions of the patients by surgical stages were as follows; there were 32 patients whose tumor stage was in 1A (%10.7), 127 patients in 1B  (42.6%), 47 patients in 1C  (15.8%), 18 patients in 2A  (6.0%), 7 patients in 2B   (2.3%), 30 patients in 3A  (10.1%), 2 patients in 3B  (0.7%), 30 patients in 3C  (10.1%), 2 patients in 4A  (0.7%) and 3 patients in 4B  (1.0%). Of the patients with endometrial cancer in our study, tumors of 102 patients were (34.2%) in grade I, 139 were (46.6%) in grade II and 57 were (19.1%) in grade III. Because endometrial cancer shows earlier symptoms than the other gynecological cancers, it can be diagnosed in early stages. There is a surgical standard treatment, but it changes according to the stages and general state of the patients.

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Author Biographies

Bulat Aytek Şık, Istanbul Aydin University

Assistant Professor, Ph.D., Istanbul Aydin University, Medicine Faculty, Deparment of Gynecology and Obstetrics

Filiz Yarşılıkal, Istanbul Kanuni Sultan Süleyman Education and Research Hospital

Op. Dr., Istanbul Kanuni Sultan Süleyman Education and Research Hospital, Deparment of Gynecology and Obstetrics

Serkan Kumbasar, Sakarya University

Op. Dr., Sakarya University, Medicine Faculty, Deparment of Gynecology and Obstetrics,

Baki Erdem, Istanbul Kanuni Sultan Süleyman Education and Research Hospital

Op. Dr., Istanbul Kanuni Sultan Süleyman Education and Research Hospital, Deparment of Gynecology and Obstetrics

Hanife Çopur, Taksim Education and Research Hospital

Op. Dr., Taksim Education and Research Hospital, Deparment of Gynecology and Obstetrics, Istanbul, Turkey

Yılda Arzu Aba, Bandırma Onyedi Eylül University

Assistant Professor, Ph.D., Bandirma Onyedi Eylul University, Health Science Faculty, Faculty of Health Science, Nursing Department, Balikesir, Turkey

References

American Cancer Society Guidelines for the Early Detection of Cancer. 2013. URL: http://www.cancer. org/healthy/findcancerearly/cancerscreeningguidelines/american-cancer-society-guidelines-for-theearly-detection-of-cancer. 28 Jun 2013.

American Joint Committee on Cancer (2010). Corpus Uteri. In Edge S, Byrd D. R., Compton C. C., Fritz A. G., Greene F. L., Trotti, A., (eds). AJCC Staging Manual, 7th. edition. New York. Springer. 2010. p. 403

Anderson, G. L., Judd, H. L., & Kaunitz, A. M. (2003). Women’s health initiative investigators. Effects of estrogen plus progestin on gynecologic cancers and associated diagnostic procedures: the women’s health initiative randomized trial. The Journal of the American Medical Association. 290 (13):1739–1748.

Ayhan, A., Kart, C., & Guven, S. (2006). The role of reoperation in the management of endometrial carcinoma found in simple hysterectomy. J Surg Oncol. 93(5):373-8.

Burbos N, Musonda P, Giarenis I, et al. (2010). Prediciting the risk of endometrial cancer in postmenopausal women prnesenting with vaginal bleeding: the Norwich Defab risk assessment tool. Br J Cancer. 102: 1201–12066

Calle, E. E., Rodriguez, C., Walker-Thurmond, K. & Thun, M. J. (2003). Overweight, obesity, and mortality from cancer in a prospectively studied cohort of US adults. The New England Journal of Medicine. 348(17): 1625–1638.

Chan, J. K., Wu, H., & Cheung, M. K. (2007). The outcomes of 27063 women with unstaged endometrioid uterine cancer. Gynecol Oncol., 106(2):282–8.

Chi, D. S, Barakat, R. R., & Palayekar, M. J. (2008). The incidence of pelvic lymph node metastasis by FIGO staging for patients with adequately surgically staged endometrial adenocarcinoma of endometrioid histology. Int J Gynecol Cancer. 18(2):269-73.

Creasman, W. T., Morrow, C. P., & Bundy, B. N. (1987). Surgical pathologic spread patterns of endometrial cancer: a Gynecologic Oncology Group study. Cancer , 60(8):2035-41.

Cust, A. E. (2011). Physical activity and gynecologic cancer prevention. Recent Results in Cancer Research. 2011; 186:159-185.

Çiçek, M. N., Akyürek, C., Çelik, Ç., & Haberal., A. (2004). Korpus Uterinin Premalign ve Malign Hastalıkları. In: Özgünen T, ed. Kadın Hastalıkları ve Doğum Bilgisi. Ankara. 2. Baskı. Güneş Kitapevi. 2004. p. 1179-205.

Doğan, N. U., Güngör, T., Özgü, E. (2008). Erken Evre Endometrium Kanserinde Lenfadenektominin Yeri. Türk Jinekolojik Onkoloji Dergisi. 3(1):53-8.

Ergör, G. (2012). Non-Communicable Diseases in Turkey. Cancer Mortality. Ed: Ünal B. Turkey Public Health Report. İzmir: 2012. s 286-287

Greenlee, R. T., Murray, T., & Bolden, S. (2000). Cancer statistic. CA Cancer J Clin. 50(1):7-33.

GLOBOCAN (2008). URL://globocan.iarc.fr/factsheets/populations/factsheet.asp?uno=900. 28 Jun 2013.

Hriack, H., Rubinstein, L.V., Gherman, G. M., & Karstaedt, N. (1991). MR imaging evaluation of endometrial carcinoma: Results of an NCI cooperative study .Radiology, 179:829-832.

Kars, B., Ünal, Ö., & Kalender, H. S. (2010). Endometrial Kanser Operasyon Sonuçlarının ve Bazı Prognostik Faktörlerin Değerlendirilmesi. Türk Jinekolojik Onkoloji Dergisi. 13(2):36-42.

Kösebay, D., Beşe, T., & Erkün, E. (1996). Endometrium kanserinde sağ kalım ve hastalıksız yaşam süresine etki eden prognostik faktörlerin değerlendirilmesi. Türkiye Klinikleri Jinekoloji ve Obstetrik Dergisi. 6(4):259-69.

Sonoda, Y., & Barakat, R. R. (2006). Screening and the prevention of gynecologic cancer: Endometrial cancer, Best Practice & Research Clinical Obstetrics and Gynaecology. 20(2):363-377.

Viswanathan, A. N., Feskanich, D., De Vivo, I., Hunter, D. J., Barbieri, R. L., Rosner, B., et al. (2005). Smoking and the risk of endometrial cancer: results from the nurses’ health study. International Journal of Cancer. 114(6): 996–1001.

Xu, W. H., Xiang, Y. B., Ruan, Z. X., Zeng, W., Cheng, J. R., Dai, Q., et al. (2004). Menstrual and reproductive factors and endometrial cancer risk: Results from a population-based case-control study in urban Shanghai. International Journal of Cancer. 108(4): 613–619.

Varpula, M. J., & Klemi, P. J. (1993). Staging of uterine endometrial carcinoma with ultralow field (0,002 T) MRI: acomparative study with CT. J. Comput Assist Tomogr, 17:641- 647.

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Published

2016-12-17

How to Cite

Şık, B. A., Yarşılıkal, F., Kumbasar, S., Erdem, B., Çopur, H., & Aba, Y. A. (2016). Retrospective analysis of cases with Endometrial Cancer. Journal of Human Sciences, 13(3), 5492–5499. Retrieved from https://j-humansciences.com/ojs/index.php/IJHS/article/view/3926

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Section

Medicine