Genotoxic, carcinogenic potential of food additives and their other effects on human health<p>Gıda katkı maddelerinin genotoksik, karsinojenik potansiyeli ve insan sağlığı üzerindeki diğer etkileri
Keywords:
Food additives, genotoxicity, cancer, allergy, neurodegenerative diseases, obesity, diabetes mellitus, gastrointestinal disorders, reproductive system disorders, Gıda katkı maddeleri, genotoksisite, kanser, alerji, nörodejeneratif hastalıklar, obeziteAbstract
The use of food additives (FAs) in food production has become an indispensable part of food technology primarily in developed countries for the last 30 years. Today, we encounter with chemical or E coded names of FAs in the ingredients written on the packages of many food products; from take-home foods to frozen products and canned goods. Some of these products, which have been increasing in terms of usage and number each passing day, have detected genotoxic and carcinogenic effects with various toxicological test systems. Besides, some of these are emerged to play role in the formation of hyperactivity, allergy, neurodegenerative diseases, obesity, diabetes, reproduction and gastrointestinal system disorders. In this review, it is aimed to give information about food additives which have been determined to have genotoxic and carcinogenic effects and reported to cause other health risks with toxicological studies.
Extended English abstract is in the end of PDF (TURKISH) file.
Özet
Son 30 yıldır gelişmiş ülkeler başta olmak üzere, gıda üretiminde katkı maddelerinin kullanımı gıda teknolojisinin vazgeçilmez bir parçası olmuştur. Günümüzde, hazır gıdalardan, dondurulmuş ürünlere ve konservelere kadar tükettiğimiz birçok gıda maddesinin ambalajlarındaki içindekiler kısmında gıda katkı maddelerinin kimyasal yada E kodlu isimleri ile karşı karşıya gelmekteyiz. Kullanımları ve sayıları her geçen gün artan bu maddelerin bazılarının genotoksik ve karsinojenik etkili olduğu çeşitli toksikolojik test sistemleriyle belirlenmiştir. Ayrıca bazılarının hiperaktivite, alerji, nörodejeneratif hastalıklar, obezite, diyabet, üreme ve gastrointestinal sisteme ilişkin bozuklukların oluşumunda rol oynadığı da ortaya çıkmıştır. Bu derlemede, toksikolojik çalışmalarla genotoksik, karsinojenik etkilere sahip olduğu ve diğer sağlık risklerine yol açtığı belirlenen gıda katkı maddeleri hakkında bilgi verilmesi amaçlanmıştır.
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