Endothelial progenitor cells and exercise: Endotel progenitör hücreler ve egzersiz

Merve Gültekinler Sadi; Rıza Darendelioğlu; Yaşar Gül Özkaya

doi:10.14687/jhs.v20i2.6359

Authors

Merve Gültekinler Sadi Akdeniz University, Institute of Health Science https://orcid.org/0000-0001-6296-8322
Rıza Darendelioğlu Akdeniz University, Institute of Health Science https://orcid.org/0000-0002-4887-8379
Yaşar Gül Özkaya Akdeniz University, Faculty of Sport Sciences https://orcid.org/0009-0000-1964-4904

DOI:

https://doi.org/10.14687/jhs.v20i2.6359

Keywords:

endotel hücre, endotel progenitör hücre, egzersiz

Abstract

The aim of the study is to investigate the effects of exercise on the cardiovascular system and especially to understand the relationship between endothelial progenitor cells (EPC) and exercise. Health sciences publications between 2003 and 2023 were searched and 8 different databases were used, examining the results of the studies in the current literature, how exercise activates EPCs, its effects on these cells and their potential mechanisms are summarized. Differences were observed in terms of exercise protocol, intensity and duration. Besides the studies showing that exercise has positive effects on vascular health, the relationship between different exercise intensities and durations is still unclear. VEGF, a key marker of angiogenesis, and CD34, a surface marker of endothelial cells, play a critical role in regulating blood vessel growth. The therapeutic potential of exercise in mobilizing EPH into the peripheral blood in persons with cardiovascular disease is not yet clear. Therefore, this study aims to evaluate the effects of single and repetitive exercise on circulating levels of EPHs in adults with cardiovascular risk factors and healthy individuals. In conclusion, it is important to investigate the relationship between physical activity and angiogenesis in more detail to better understand the effects of exercise on vascular health. These studies will help us better understand the potential of exercise and physical activity in the treatment and prevention of cardiovascular diseases.

Extended English summary is in the end of Full Text PDF (TURKISH) file.

Özet

Çalışmanın amacı, egzersizin kardiyovasküler sistem üzerindeki etkilerini araştırmak ve özellikle endotel progenitör hücreler (EPC) ile egzersiz arasındaki ilişkiyi anlamaktır. Sağlık bilimleriyle ilgili 2003-2023 yılları arasında yapılan yayınlar taranmış ve 8 farklı veri tabanı kullanılmış olup, mevcut literatürdeki araştırmaların sonuçlarını inceleyerek egzersizin EPC'leri nasıl harekete geçirdiği ve bu hücreler üzerindeki etkileri ve potansiyel mekanizmaları özetlenmiştir. Egzersiz protokolü, yoğunluk ve süre açısından farklılıklar gözlenmiştir. Egzersizin, damar sağlığı üzerinde olumlu etkilerinin olduğunu gösteren çalışmaların yanı sıra farklı egzersiz yoğunlukları ve süreleri arasındaki ilişki hala belirsizdir. Anjiyogenezin anahtar belirteci olan VEGF ve endotel hücrelerin yüzey belirteci olan CD34, kan damarı büyümesini düzenlemede kritik bir rol oynamaktadır. Kardiyovasküler hastalığı olan kişilerde, EPH periferik kana mobilizasyonunda egzersizin terapötik potansiyeli henüz net değildir. Bu nedenle, bu çalışma, kardiyovasküler risk faktörlerine sahip erişkinlerde ve sağlıklı bireylerde EPH'lerin dolaşım seviyelerinde tek ve tekrarlayan egzersizin etkilerini değerlendirmeyi amaçlamaktadır. Sonuç olarak, egzersizin damar sağlığı üzerindeki etkilerini daha iyi anlamak için fiziksel aktivite ve anjiyogenez arasındaki ilişkiyi daha ayrıntılı bir şekilde araştırmak önemlidir. Bu çalışmalar, kardiyovasküler hastalıkların tedavisi ve önlenmesinde egzersiz ve fiziksel aktivitenin potansiyelini daha iyi anlamamıza yardımcı olacaktır.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

References

Bloor, C. M. (2005). "Angiogenesis during exercise and training." Angiogenesis 8(3): 263-271.

Cavalcante, S., ve ark. (2022). "Endothelial Progenitor Cell Response to Acute Multicomponent Exercise Sessions with Different Durations." Biology 11(4): 572.

Chang, E., ve ark. (2015). "Exercise induces SDF-1 mediated release of endothelial progenitor cells with increased Vasculogenic function." Plastic and Reconstructive Surgery 135(2): 340e.

Eleuteri, E., ve ark. (2013). "Aerobic training and angiogenesis activation in patients with stable chronic heart failure: a preliminary report." Biomarkers 18(5): 418-424.

Ferentinos, P., ve ark. (2022). "The impact of different forms of exercise on circulating endothelial progenitor cells in cardiovascular and metabolic disease." European Journal of Applied Physiology 122(4): 815-860.

Gagliardi, J. A., ve ark. (2016). "Relationship between endothelial progenitor cells and vascular endothelial growth factor and its variation with exercise." Thrombosis Research 137: 92-96.

Heinisch, P. P., ve ark. (2022). "Endothelial progenitor cells as biomarkers of cardiovascular pathologies: A narrative review." Cells 11(10): 1678.

Jensen, L., ve ark. (2004). "Effect of high intensity training on capillarization and presence of angiogenic factors in human skeletal muscle." The Journal of physiology 557(2): 571-582.

Kourek, C., ve ark. (2021). "The acute and long-term effects of a cardiac rehabilitation program on endothelial progenitor cells in chronic heart failure patients: Comparing two different exercise training protocols." IJC Heart & Vasculature 32: 100702.

Lansford, K. A., ve ark. (2016). "Effect of acute exercise on circulating angiogenic cell and microparticle populations." Experimental physiology 101(1): 155-167.

Luk, T.-H., ve ark. (2012). "Effect of exercise training on vascular endothelial function in patients with stable coronary artery disease: a randomized controlled trial." European journal of preventive cardiology 19(4): 830-839.

Mezzani, A., ve ark. (2013). "Speeding of pulmonary VO2 on-kinetics by light-to-moderate-intensity aerobic exercise training in chronic heart failure: clinical and pathophysiological correlates." International journal of cardiology 167(5): 2189-2195.

Muggeridge, D., ve ark. (2021). "CD34+ progenitors are predictive of mortality and are associated with physical activity in cardiovascular disease patients." Atherosclerosis 333: 108-115.

Niemiro, G. M., ve ark. (2017). "Kinetics of circulating progenitor cell mobilization during submaximal exercise." Journal of Applied Physiology 122(3): 675-682.

Ribeiro, F., ve ark. (2013). "Effects of exercise training on endothelial progenitor cells in cardiovascular disease: a systematic review." American journal of physical medicine & rehabilitation 92(11): 1020-1030.

Ross, M. D., ve ark. (2018). "Lower resting and exercise-induced circulating angiogenic progenitors and angiogenic T cells in older men." American Journal of Physiology-Heart and Circulatory Physiology 314(3): H392-H402.

Sandri, M., ve ark. (2016). "Chronic heart failure and aging–effects of exercise training on endothelial function and mechanisms of endothelial regeneration: Results from the Leipzig Exercise Intervention in Chronic heart failure and Aging (LEICA) study." European journal of preventive cardiology 23(4): 349-358.

Schlager, O., ve ark. (2011). "Exercise training increases endothelial progenitor cells and decreases asymmetric dimethylarginine in peripheral arterial disease: a randomized controlled trial." Atherosclerosis 217(1): 240-248.

Van Craenenbroeck, E. M., ve ark. (2008). "Quantification of circulating endothelial progenitor cells: a methodological comparison of six flow cytometric approaches." Journal of Immunological Methods 332(1-2): 31-40.

Van Craenenbroeck, E. M., ve ark. (2010). "Exercise training improves function of circulating angiogenic cells in patients with chronic heart failure." Basic research in cardiology 105: 665-676.

Yan, F., ve ark. (2022). "Paracrine mechanisms of endothelial progenitor cells in vascular repair." Acta Histochemica 124(1): 151833.

Yang, Z., ve ark. (2007). "Acute exercise-induced nitric oxide production contributes to upregulation of circulating endothelial progenitor cells in healthy subjects." Journal of human hypertension 21(6): 452-460.